Production of PMSG in Iceland

1. The hidden blood business

Before the publication of our documentary film “Iceland – Land of the 5,000 Blood Mares”in November 2021, few people in Iceland and abroad knew about the blood business. Every year, around 5,000 pregnant Icelandic mares are repeatedly exposed to high-volume blood collections for the production of Pregnant Mare Serum Gonadotropin (PMSG)

Production of the fertility hormone PMSG is a “big business” in Iceland that has existed for around 40 years and has been growing considerably in the past decade. There is only one pharmaceutical company in Iceland trading in PMSG: Isteka ehf. The company mainly acquires the mares’ blood from independent farms. Blood is processed at Isteka’s laboratory into a pure PMSG powder and sold to pharmaceutical companies abroad. Fertility drugs serve for the induction and synchronisation of oestrus in farmed animals. 


Most of the mares used for blood collection in Iceland come from the meat industry. The farmers receive income by selling the blood of the pregnant mares to Isteka and by selling the foals, often for slaughter. Nowadays, the production of PMSG is far more lucrative than the production of horsemeat. According to informants, foals are just a cheap by-product of the blood business, and the price of slaughtering foals has dropped drastically in the past years.

After repeated public scandals about PMSG production in Argentina and Uruguay, involving severe mistreatment of blood mares, several pharmaceutical companies stopped the import of PMSG from South America, in particular Ceva Santé Animale, Intervet/MSD Animal Health and IDT Biologika. Since then, they have been sourcing PMSG from Europe. The main European producer of the hormone is Iceland. Thus, we decided to look into the Icelandic blood business.

We started our investigations in August 2019 and completed them in September 2021. Our findings clearly show that blood collection in Iceland is not an animal-friendly alternative to South America and that it is high time that the trade with the blood of pregnant mares is coming to an end.

2. PMSG: One of the driving forces behind industrial farming

Pregnant mare serum gonadotropin (PMSG), also called equine chorionic gonadotropin (eCG), is a hormone found in the blood of mares during the first stage of pregnancy (from day 40 to 140). The mares are subjected to repeated blood extractions over a period of approx. two months, depending on the hormone level in their blood.

The fertility hormone PMSG is predominantly used in industrial animal breeding to increase the reproductive performance of farmed animals - in particular sows, but also cattle, sheep, and goats - through synchronising cycles and increasing the number of offspring produced per year. The use of PMSG in intensive pig farming is very common all over the world. By using PMSG, the sows come in heat earlier after weaning the piglets and can be inseminated earlier than under natural conditions. In the marketing brochure for the product Fertipig, the pharmaceutical company Ceva Santé Animale recommends treating all sows at the day of weaning in a preventive way. There are approx. 1.6 million breeding sowsin Germany. Since 2.1 million doses of PMSG are administered per year, it is clear that PMSG is not only used to treat individual animals in case of anoestrus but is rather used systematically in piglet production. Furthermore, PMSG is also used for superovulation and induction of puberty.

Ceva’s marketing brochure defines the goals of PMSG use as follows:

  • higher insemination rate
  • higher number of piglets
  • less non-productive days
  • better concentration of work and increased economic efficiency.

It is clear that the hormone serves to boost fertility and profits in industrial farming.

Negative impact on the welfare of farmed animals

The production of PMSG not only raises serious welfare concerns with regard to horses. Horses are exploited in order to exploit other species, mainly pigs. PMSG promotes unnatural rates of reproduction and gives the sows no time to recover in between pregnancies. PMSG also induces superovulation which results in larger litter sizes. Surplus piglets often die or are killed when a sow does not have enough teats to feed them all. Increased litter size is evidently associated with increased piglet mortality. Furthermore, PMSG can be used for the induction of puberty in young sows, but early pregnancy shortens pubertal development and usually leads to early infertility and slaughter.

There is no medical indication for the frequent application of PMSG in farmed animals. The practice only serves economic interests by stimulating and accelerating physiological processes in animals. Furthermore, PMSG is used to treat fertility problems which are caused by the system, namely by poor husbandry conditions in intensive farming.  

Alternatives to PMSG

According to veterinary experts, induction and synchronisation of oestrus is also possible with zootechnical methods such as exercise, optimal nutrition and lighting, contact with sows in oestrus and boar contact. Such measures are, for instance, used in organic farming. Furthermore, there are numerous synthetic alternatives available to breeders for the induction and synchronisation of oestrus in farmed animals – 36 products in Germany alone – and their efficacy is very similar to PMSG according to different studies. In Germany, there is a training project for farmers and veterinarians  which transfers knowledge about alternatives to PMSG use in pig breeding.

3. Findings of our investigations

Isteka’s image film   shows the blood extraction as a peaceful procedure taking place in a calm environment, with the people involved displaying competence and expertise. The everyday reality looks very different, as we documented during investigations in 2019 and 2021.

  • 2019

During ten days of investigation, we find and document 40 blood farms in Iceland out of around 100 farms. In the north of the country, blood collection often takes place inside buildings due to harsh weather conditions. In the south, most blood collection facilities are in the open. We detect numerous risks of injury to the mares at these facilities. Most raceways and restraint boxes have dangerous gaps where the mares can injure their legs, and the boxes often have low bars where they can sustain head injuries.

The farms contracted by Isteka keep on average 30 to 70 mares, with some farms having considerably more. Isteka itself runs several blood farms and owns hundreds of mares. Most mares that are used for PMSG and meat production are semi-wild. Thus, blood extraction is a very stressful procedure. During a farm visit together with Isteka, we observe frightened mares struggling in the restraint box. Despite the audit situation, we observe some rough handling when the farmers believe they are not being watched.

At another blood farm, where we observe activities from a distance, people repeatedly hit mares with sticks, including on their heads. In addition, dogs are used to round up the horses, and one is observed attacking them. Furthermore, we find a seriously injured mare in a pasture next to a blood farm. The mare does not receive any appropriate care over four days, although we have informed the veterinary authority MAST.


  • 2021

Video footage obtained on two blood farms in 2021 shows the everyday treatment of the mares outside the audit situation. The entire procedure, lasting two to three hours, is stressful for the semi-wild horses. Their handling is rough to brutal; their blood is taken by force.

The mares are packed tightly together in overcrowded holding pens, where they fight frequently and foals risk being injured. The mares are forced into the restraint boxes by being beaten with whips, rubber sticks, iron rods or wooden planks. None of the veterinarians present is observed intervening to stop the mistreatment. The mares are restrained inside the boxes with their heads tied up high, and a large-bore cannula is inserted into their jugular vein.

Panicked mares struggle to get free and pull at the rope. Some fall. Their entire weight is borne by their head and neck, putting them at risk of serious injuries. After the blood extraction, most of the traumatised mares run away as quickly as they can, while others walk away slowly, shaking their whole body or even staggering.

4. Legal situation of PMSG production in Iceland

In Iceland, there is no legislation that has specific requirements for blood collection from pregnant mares, such as a maximum blood volume or frequency. PMSG production is not mentioned in any legislation.

  • Unnecessary "animal experiments"

The production of PMSG is approved by the veterinary authority MAST as animal experimentation, based on Regulation no. 460/2017 on the protection of animals used for scientific purposes, which implements the EU Directive no. 2010/63 with EEA relevance. Procedures for the manufacture of drugs - such as blood collections - are classified as animal experiments. However, the EU and Icelandic legislation on animal testing is based on the principle of the 3 Rs: replacement, reduction and refinement. According to this principle, animals may only be used in experiments if there are no alternative methods available. Since there are numerous synthetic drugs that fulfil the same purpose as PMSG, and since good fertility in farmed animals can also be achieved without using hormones, the indispensability requirement for animal experiments is not fulfilled. The commercially conducted blood collections from pregnant mares are unnecessary and should not be approved by the authorities.

  • Systematic breaches of Icelandic animal welfare legislation

The goal of the Animal Welfare Law no. 55/2013 is that animals are free from discomfort, fear, suffering, pain and injury, inter alia, in the light that animals are sentient beings. Ill-treatment of animals is prohibited. However, it is not possible to take blood from semi-wild horses without using force or causing stress and fear. This is a systematic problem and leads to repeated traumatisation of the mares, as stated by veterinary experts. Furthermore, the coercive restraint in the blood extraction boxes poses many risks of injuries. It is unrealistic and not economically viable to tame and train 5,300 mares so that their blood could be extracted safely, without creating unnecessary stress and fear.

The scenes of animal abuse shown in our documentary film are not individual cases or exceptions. The film shows three blood farms in operation, two of them in detail. We visited a fourth blood farm together with Isteka’s manager but were not allowed to film or take pictures. We detected systematic animal welfare violations at all four blood farms, thus at 100 % of the farms we saw in operation. Severe animal cruelty, such as beatings, could only be filmed when the people concerned felt unobserved.

According to the Horse Welfare Regulation no. 910/2014, performing procedures on horses for no medical reason is prohibited, which is clearly the case here. Even the use of PMSG in farmed animals does not serve medical purposes but purely economic ones.

5. Non-compliance with existing recommendations on blood volumes

From late summer to autumn, 5 litres of blood are drawn from each mare once a week, up to 8 or even 10 times per season. This frequency exceeds any existing international recommendations for blood collection. Some guidelines recommend that no more than 10 % of a horse’s total blood volume should be extracted every 3 to 4 weeks. Others recommend a maximum of 15 % every 4 weeks. It is further not recommended to remove more than 15 % of the blood volume due to the risk of hypovolemic shock. Icelandic horses have a total blood volume of about 28.5 litres. Thus, according to various recommendations, no more than 4.275 litres (15 %) should be extracted once per month. In Iceland, between 15 and 20 % of the mares’ total blood volume is removed once a week. The implementation of the recommended standards would drastically reduce the production volume by approx. 75 %. Such a significant reduction would go against the interests of Isteka, especially since the company is planning to increase the production further in the coming years.

According to German guidelines for the collection of blood in the veterinary field, a maximum of 15 ml blood per kilogram body weight may be extracted every 30 days, which in the case of Icelandic horses would make 5.7 litres once per month. However, these guidelines additionally prohibit taking blood from pregnant or lactating mares. In Iceland, the mares are both pregnant and lactating, which must also be taken into account. According to Prof. Stephanie Krämer from the Justus Liebig University Giessen, the mares have to provide energy for the production of milk and also for the development of the foetus. In addition, they have to provide energy for the regeneration of lost blood components, which means a triple burden for the mares.


6. Conclusion

Our recent investigations show that blood collection from pregnant, semi-wild mares in Iceland is a business that raises serious animal welfare concerns, including:

  • High volume and frequency of blood extractions, raising both animal health and welfare concerns
  • Rough or violent handling of mares during the blood extraction procedure
  • Untamed mares exhibiting severe signs of stress, fear or panic (repeated traumatisation)
  • Installations and methods of restraint posing a high risk of injury to the mares
  • Insufficient supervision by the responsible veterinarian and by the veterinary authority MAST
  • Untrained staff

PMSG is a cruelly produced hormone, and it is not indispensable since there are numerous alternative methods available to breeders. PMSG only serves to maximise profits of blood farmers, pharmaceutical companies and industrial animal breeders.

EU Parliament’s call for a ban on PMSG import and production 

On 20th October 2021, the European Parliament adopted by a large majority a Resolution on a Farm to Fork Strategy for a fair, healthy and environmentally-friendly food system. In its paragraph 130, the European Parliament “recalls that structural animal experiments that are not indispensable should have no place in the food chain as Directive 2010/63/EU prescribes the replacement and reduction of the use of animals in procedures; calls on the Commission and Member States to stop the import and domestic production of Pregnant Mare Serum Gonadotropin (PMSG), which is extracted from the blood of pregnant horses that are systematically impregnated and exposed to blood collections, involving health and welfare issues”.

This call represents the official position of the European Parliament, even if it is not legally binding on the European Commission. It is high time for the European Commission to act and implement the Parliament’s request.

We urge the European Commission to follow the European Parliament’s call and to ban EU imports and production of PMSG

7. Documentary films

“Iceland - Land of the 5,000 Blood Mares”:

A 120-page dossier on PMSG production in Iceland can be made available, on request, to competent authorities, politicians and media representatives.